LRP in Alzheimer's disease: friend or foe?

نویسندگان

  • P G Ulery
  • D K Strickland
چکیده

Alzheimer’s disease (AD) is a neurodegenerative disorder and the leading cause of senile dementia. The brains of AD patients show two major pathological hallmarks: amyloid or senile plaques (SPs) and neurofibrillary tangles (NFTs). While NFTs are bundles of protein filaments found in the cytoplasm of neurons, SPs are extracellular aggregates of insoluble protein fibrils. The major component of SPs is a small, hydrophobic peptide termed amyloid β peptide (Aβ), which is derived from a ubiquitous type I transmembrane protein of unknown function named amyloid precursor protein (APP) (1).

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عنوان ژورنال:
  • The Journal of clinical investigation

دوره 106 9  شماره 

صفحات  -

تاریخ انتشار 2000